Abstract
A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the compounds have shown promising antimicrobial activity.
Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.
Anti-Infective Agents
Title:Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones
Volume: 12 Issue: 1
Author(s): Radhe S. Bahare and Swastika Ganguly
Affiliation:
Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.
Abstract: A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the compounds have shown promising antimicrobial activity.
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Cite this article as:
Bahare Radhe S. and Ganguly Swastika, Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones, Anti-Infective Agents 2014; 12 (1) . https://dx.doi.org/10.2174/221135251201140102003059
DOI https://dx.doi.org/10.2174/221135251201140102003059 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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