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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

DHA: An Excellent Source of Bioactive Heterocycles

Author(s): Girish Kumar Gupta, Ankit Mittal and Vinod Kumar

Volume 11, Issue 4, 2014

Page: [273 - 286] Pages: 14

DOI: 10.2174/1570178610666131230235759

Price: $65


Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.

Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.

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