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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

Author(s): Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan

Volume 17 , Issue 6 , 2014

Page: [503 - 508] Pages: 6

DOI: 10.2174/1386207316666131229132950

Price: $65

Abstract

A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.

Keywords: Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.


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