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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Novel Approach for the Synthesis of Pyrrolo[2,1-c][1,4]Benzoxazines and Pyrrolo[1,2-a]Quinoxalines

Author(s): Tayebeh Sanaeishoar, Somayeh Adibi-Sedeh and Saghar Karimian

Volume 17, Issue 2, 2014

Page: [157 - 161] Pages: 5

DOI: 10.2174/1386207316666131227150430

Price: $65


An efficient synthesis of alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[2,1-c][1,4]benzoxazine-3-carboxylates and alkyl 4,5-dihydro-4-oxo-2-phenylpyrrolo[1,2-a]quinoxaline-3-carboxylates is described. This involves a three-component reaction between o-aminophenols or o-phenylenediamine, acetylenic esters and β-nitrostyrene derivatives using p-toluene sulfonic acid as a catalyst.

Keywords: o-aminophenols, o-phenylenediamine, p-toluene sulfonic acid, pyrrolo[1, 2-a]quinoxaline, pyrrolo[2, 1-c][1, 4]benzoxazine, β- nitrostyrenes.

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