Generic placeholder image

CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

The Canonical Wnt Signaling Pathway in Autism

Author(s): Yinghua Zhang, Xiangshan Yuan, Zhongping Wang and Ruixi Li

Volume 13, Issue 5, 2014

Page: [765 - 770] Pages: 6

DOI: 10.2174/1871527312666131223114149

Price: $65


Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the canonical Wnt pathway may exert adverse effects on neurodevelopment and therefore leads to the pathogenesis of autism. Here, we review human and animal studies that implicate the canonical Wnt signal transduction pathway in the pathogenesis of autism. We also describe the crosstalk between the canonical Wnt pathway and the Notch signaling pathway in several types of autism spectrum disorders, including Asperger syndrome and Fragile X. Further research on the crosstalk between the canonical Wnt signaling pathway and other signaling cascades in autism may be an efficient avenue to understand the etiology of autism and ultimately lead to alternative medications for autism-like phenotypes.

Keywords: Autism, β-catenin, notch, signaling crosstalk, Wnt.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy