Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review

Author(s): S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar

Volume 19 , Issue 41 , 2013

Page: [7203 - 7218] Pages: 16

DOI: 10.2174/138161281941131219124142


Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload drugs within the nanogel matrix, the high stability in aqueous media, their stimuli responsively behavior potential, and the versatility in release drugs in a controlled manner make them very attractive for use in the area of drug delivery. The materials used for the preparation of nanogels ranged from natural polymers like ovalbumin, pullulan, hyaluronic acid, methacrylated chondroitin sulfate and chitosan, to synthetic polymers like poly (N-isopropylacrylamide), poly (Nisopropylacrylamide- co-acrylic acid) and poly (ethylene glycol)-b-poly (methacrylic acid). The porous nanogels have been finding application as anti-cancer drug and imaging agent reservoirs. Smart nanogels responding to external stimuli such as temperature, pH etc can be designed for diverse therapeutic and diagnostic applications. The nanogels have also been surface functionalized with specific ligands aiding in targeted drug delivery. This review focus on stimuli-sensitive, multi-responsive, magnetic and targeted nanogels providing a brief insight on the application of nanogels in cancer drug delivery and imaging in detail.

Keywords: Nanogels, hydrogels, magnetic, stimuli-responsive, multi-responsive, targeted, biodegradable polymers, cancer drug delivery, anticancer drugs, imaging.

© 2022 Bentham Science Publishers | Privacy Policy