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Current Metabolomics

Editor-in-Chief

ISSN (Print): 2213-235X
ISSN (Online): 2213-2368

Advances in Metabonomics on Infectious Diseases

Author(s): Hongde Li, Huiru Tang and Yulan Wang

Volume 1 , Issue 4 , 2013

Page: [318 - 334] Pages: 17

DOI: 10.2174/2213235X01666131219000034

Abstract

Metabonomics is a powerful holistic approach for biomarker discovery and an effective tool for pinpointing endpoint metabolic effects of external stimuli, such as pathogens. Therefore, metabonomics is a promising method to enhance our understanding of infection mechanism, and holds potential for discovery of novel targets for diagnostics, drugs and vaccines. Due to advances in metabonomics technology, emerging research on infectious diseases in the past decade has been reported. In this review, we emphasise the importance of host metabolic responses to infectious pathogens, including viruses, bacteria and parasites, in the understanding mechanism of infection and potential for diagnostic capability. Researches carried on cell, animal and human models are included. Finally, we conclude with a section on research needs for improved analytical techniques and integrative systems biological approach for in-depth understanding mechanisms of infection.

Keywords: Bacterium, infection, metabolism, metabonomics, parasite, pathogen, virus.


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