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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections

Author(s): Kathryn E. McGovern and Emma H. Wilson

Volume 9 , Issue 3 , 2013

Page: [157 - 168] Pages: 12

DOI: 10.2174/1573395509666131217000000

Price: $65

Abstract

Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the immune response to achieve optimal control of parasite replication without promoting pathology.

Keywords: CCL21, CCR7, cell trafficking, chemokine, parasite, Toxoplasma.


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