Abstract
Breakthroughs in genetics over the last decade have radically advanced our understanding of the etiological basis of Parkinson's disease (PD). Although much research remains to be done, the main genetic causes of this neurodegenerative disorder are now partially unraveled, allowing us to feel more confident that our knowledge about the genetic architecture of PD will continue to increase exponentially. How and when these discoveries will be introduced into general clinical practice, however, remains uncertain. In this review, we provide a general summary of the progress in the genetics of PD and discuss how this knowledge will contribute to the diagnosis and clinical management of patients with, or at risk of this disorder.
Keywords: Genetics, Parkinson's disease, Mendelian genes, Genetic testing, PARK, Clinical genetics, Genetic risk factor.
Current Genomics
Title:Parkinson's Disease: From Genetics to Clinical Practice
Volume: 14 Issue: 8
Author(s): Jordi Clarimon and Jaime Kulisevsky
Affiliation:
Keywords: Genetics, Parkinson's disease, Mendelian genes, Genetic testing, PARK, Clinical genetics, Genetic risk factor.
Abstract: Breakthroughs in genetics over the last decade have radically advanced our understanding of the etiological basis of Parkinson's disease (PD). Although much research remains to be done, the main genetic causes of this neurodegenerative disorder are now partially unraveled, allowing us to feel more confident that our knowledge about the genetic architecture of PD will continue to increase exponentially. How and when these discoveries will be introduced into general clinical practice, however, remains uncertain. In this review, we provide a general summary of the progress in the genetics of PD and discuss how this knowledge will contribute to the diagnosis and clinical management of patients with, or at risk of this disorder.
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Cite this article as:
Clarimon Jordi and Kulisevsky Jaime, Parkinson's Disease: From Genetics to Clinical Practice, Current Genomics 2013; 14 (8) . https://dx.doi.org/10.2174/1389202914666131210212305
DOI https://dx.doi.org/10.2174/1389202914666131210212305 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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