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Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued)


ISSN (Print): 2212-7038
ISSN (Online): 2212-7046

Synthesis and Pharmacological Studies of Novel 3-Substituted Indole Derivatives as Potential Anti-Inflammatory and Analgesic Agents

Author(s): Mayura A. Kale, Ashok S. Narute and Tukaram M. Kalyankar

Volume 1, Issue 1, 2014

Page: [39 - 44] Pages: 6

DOI: 10.2174/2212703801666131209232632


Facile synthesis of some novel anti-inflammatory and analgesic agents was established by initially treating 3- acetyl indole (1) with the various aromatic aldehydes (2) which afforded the corresponding 3-chalconylindoles 3a-e. These products 3a-e upon treatment with hydrazine hydrate gave the resultant pyrazoline derivatives 4a-e. Also, the diazotized salt of aniline, when reacted with these pyrazoline indoles 4a-e yielded azo derivatives of pyrazoline indoles 5a-e. These newly synthesized compounds were screened for the mentioned activities and were found to possess good potential to act against inflammation and pain.

Keywords: Analgesic & indomethacin, anti-inflammatory, azo derivatives, indole, pyrazoline.

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