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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Basal Septal Hypertrophy

Author(s): Mihir A. Kelshiker, Jamil Mayet, Beth Unsworth and Darlington O. Okonko

Volume 9, Issue 4, 2013

Page: [325 - 330] Pages: 6

DOI: 10.2174/1573403X09666131202125424

Price: $65


A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild hypertension. The topic of breathlessness in patients with clinical heart failure, but who have a normal ejection fraction (HFNEF) has attracted significant controversy over the past few years. This review aims to analyse the literature on BSH, identify the possible associations between BSH and HFNEF, and consequently explore possible pathophysiological mechanisms whereby clinical symptoms are experienced.

Keywords: Basal septal hypertrophy, diastolic dysfunction, HFNEF, outflow tract obstruction.

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