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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Cellular Actions of Nesfatin-1 on Hypothalamic and Medullary Neurons

Author(s): Andrea Mimee and Alastair V. Ferguson

Volume 19 , Issue 39 , 2013

Page: [6949 - 6954] Pages: 6

DOI: 10.2174/138161281939131127125347

Price: $65


The present review summarizes the current understanding of the neuronal activation patterns induced by nesfatin-1 in both the hypothalamus and the brainstem, as well as the physiological outcomes caused by the activation of these neuronal populations. Studies using cFos measurements, Ca2+ imaging techniques, electrophysiological recordings, and microinjections have led to the identification of the paraventricular nucleus, arcuate nucleus, lateral and ventromedial hypothalamic areas, as well as medullary centers such as the nucleus of the solitary tract and dorsal motor nucleus of the vagus as targets of central nesfatin-1 actions on food intake, cardiovascular function, stress responses, and glucose homeostasis.

Keywords: Nesfatin-1, paraventricular nucleus, arcuate nucleus, nucleus of the solitary tract, cFos, Ca2+ imaging, electrophysiology, microinjection.

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