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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Complex Inheritance for Susceptibility to Sudden Cardiac Death

Author(s): Raha Pazoki, Michael W.T. Tanck, Arthur A.M. Wilde and Connie R. Bezzina

Volume 19, Issue 39, 2013

Page: [6864 - 6872] Pages: 9

DOI: 10.2174/138161281939131127112906

Price: $65


Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.

Keywords: Ventricular arrhythmia, genome-wide association studies, sudden cardiac death, genetics.

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