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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Functional Roles of Benzothiazole Motif in Antiepileptic Drug Research

Author(s): Mohammad Amir and Mohd. Zaheen Hassan

Volume 13, Issue 14, 2013

Page: [2060 - 2075] Pages: 16

DOI: 10.2174/1389557513666131119203036

Price: $65


Benzothiazoles are promising candidates for the design of novel antiepileptic drugs. The endocyclic sulphur and nitrogen functions present in this heterocyclic nucleus have been shown to be critical for the anticonvulsant activity. The present review outlines the rational design and anticonvulsant potential of promising benzothiazole lead molecules. Particular focus has been placed on the structure activity relationship of different benzothiazole derivatives giving selected examples of molecules with significant activity being that these molecules may serve as prototypes for the development of more active antiepileptic drugs.

Keywords: Anticonvulsant activity, benzothiazole, pharmacophore, SAR.

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