Abstract
Attempts to induce stereoselectivity in the conjugate addition to the α,β-unsaturated acceptors have been investigated by numerous research groups, classically through the use of either a chiral acceptor or chiral donor component in the reaction. The asymmetric Michael addition catalyzed by chiral catalysts has been extensively proven and established to be a powerful synthetic tool for especially a range of asymmetric syntheses of natural products and various heterocyclic systems.
This review covers the recent reports and further applications of this methodology in the formation of carbon-carbon bond between or within functionalized and sensitive substrates which provides new opportunities, mainly in the total synthesis, medicinal and process chemistry, nanotechnology and chemical biology.
Keywords: Asymmetric conjugation, C-C bond formation, chiral reagent, chiral catalyst, enolizable carbonyl derivatives, Michael addition.
Current Organic Chemistry
Title:Recent Development in the Asymmetric Michael Addition for Carbon-Carbon Bond Formation
Volume: 18 Issue: 4
Author(s): Majid M. Heravi, Parvin Hajiabbasi and Hoda Hamidi
Affiliation:
Keywords: Asymmetric conjugation, C-C bond formation, chiral reagent, chiral catalyst, enolizable carbonyl derivatives, Michael addition.
Abstract: Attempts to induce stereoselectivity in the conjugate addition to the α,β-unsaturated acceptors have been investigated by numerous research groups, classically through the use of either a chiral acceptor or chiral donor component in the reaction. The asymmetric Michael addition catalyzed by chiral catalysts has been extensively proven and established to be a powerful synthetic tool for especially a range of asymmetric syntheses of natural products and various heterocyclic systems.
This review covers the recent reports and further applications of this methodology in the formation of carbon-carbon bond between or within functionalized and sensitive substrates which provides new opportunities, mainly in the total synthesis, medicinal and process chemistry, nanotechnology and chemical biology.
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Cite this article as:
Heravi M. Majid, Hajiabbasi Parvin and Hamidi Hoda, Recent Development in the Asymmetric Michael Addition for Carbon-Carbon Bond Formation, Current Organic Chemistry 2014; 18 (4) . https://dx.doi.org/10.2174/13852728113176660149
DOI https://dx.doi.org/10.2174/13852728113176660149 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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