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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents

Author(s): M. Ashfaq, S.S.A. Shah, T. Najam, M.M. Ahmad, R. Tabassum and G. Rivera

Volume 21 , Issue 7 , 2014

Page: [911 - 931] Pages: 21

DOI: 10.2174/09298673113206660302

Price: $65

Abstract

Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron- withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.

Keywords: Antituberculosis, benzimidazoles, carboxylic acid, design, quinolones, thioamides.


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