In Vitro Antitumoral Activity of Palladium(II) and Platinum(II) Complexes with O,O'-Dialkyl Esters of Ethylene-bis(S)-Leucine

Title:In Vitro Antitumoral Activity of Palladium(II) and Platinum(II) Complexes with O,O'-Dialkyl Esters of Ethylene-bis(S)-Leucine

Volume: 11 Issue: 4

Author(s): Jelena M. Vujic, Goran N. Kaluderovic, Tatjana P. Stanojkovic, Jadranka A. Antic and Srecko R. Trifunovic

Affiliation:

Keywords: Palladium(II) complexes, Platinum(II) complexes, EDDA-type ligands, Human breast cancer, T-leukemia, Chronic myelogenous leukaemia.

Abstract: Cytotoxic activity of four O,O'-dialkyl esters of ethylene-bis(S)-leucine [(S,S)-ethylenediamine-N,N’-di-2-(4- methyl)pentanoic acid] dihydrochlorides, R2edda-type esters L1.2HCl–L4.2HCl (alkyl = Et, n-Pr, n-Bu, and n-Pe, respectively), and corresponding palladium(II) (1–4) and platinum(II) (5–8) complexes against MDA-MB-361, MDA-MB-453 (human breast cancer), Jurkat (T-leukemia) and K562 (chronic myelogenous leukaemia) cell lines were determined. Results indicate cytotoxic potential of the investigated complexes based on induction of apoptosis.

Cite this article as:

Vujic M. Jelena, Kaluderovic N. Goran, Stanojkovic P. Tatjana, Antic A. Jadranka and Trifunovic R. Srecko, In Vitro Antitumoral Activity of Palladium(II) and Platinum(II) Complexes with O,O'-Dialkyl Esters of Ethylene-bis(S)-Leucine, Letters in Drug Design & Discovery 2014; 11(4) . https://dx.doi.org/10.2174/15701808113106660092