Abstract
Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several signaling molecules. A paradigm shift emerged when an alternative direct signaling pathway was discovered: RTKs may move from cell surface to nucleus where they transduce the signals in a direct way. More recently, evidence has accumulated that RTKs may also translocate to mitochondria and regulate their functions, i.e., by altering tyrosine phosphorylation of specific mitochondrial proteins. This latter emerging pathway is here reviewed and discussed.
Keywords: EGFR, ErbB-2, FGFR-1, FLT-3, mitochondria, neurotrophin receptors, tyrosine kinase receptors, tyrosine phosphorylation.
Current Protein & Peptide Science
Title:Receptor Tyrosine Kinases Take a Direct Route to Mitochondria: An Overview
Volume: 14 Issue: 7
Author(s): Mauro Salvi
Affiliation:
Keywords: EGFR, ErbB-2, FGFR-1, FLT-3, mitochondria, neurotrophin receptors, tyrosine kinase receptors, tyrosine phosphorylation.
Abstract: Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several signaling molecules. A paradigm shift emerged when an alternative direct signaling pathway was discovered: RTKs may move from cell surface to nucleus where they transduce the signals in a direct way. More recently, evidence has accumulated that RTKs may also translocate to mitochondria and regulate their functions, i.e., by altering tyrosine phosphorylation of specific mitochondrial proteins. This latter emerging pathway is here reviewed and discussed.
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Cite this article as:
Salvi Mauro, Receptor Tyrosine Kinases Take a Direct Route to Mitochondria: An Overview, Current Protein & Peptide Science 2013; 14 (7) . https://dx.doi.org/10.2174/13892037113146660087
DOI https://dx.doi.org/10.2174/13892037113146660087 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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