Abstract
An efficient synthesis of 2-substituted benzoxazoles via copper acetate monohydrate oxidative coupling of aldehydes with o-aminophenol is described. This synthetic strategy has some advantages as simple procedure, inexpensive and easily available catalyst, and facile isolation of the products in moderate to good yields.
Keywords: Benzoxazoles, aromatic aldehydes, o-aminophenol, copper acetate monohydrate, oxidative cyclization.
Letters in Organic Chemistry
Title:One-pot Synthesis of 2-Substituted Benzoxazoles Promoted by Copper Acetate Monohydrate
Volume: 11 Issue: 3
Author(s): Guo-Feng Chen, Hai-Dong Shen, Li-Yan Zhang, Hong-Yang Li, Rui-Jia Lan, Bao-Hua Chen, Ji-Tai Li and Qing-Hui Hu
Affiliation:
Keywords: Benzoxazoles, aromatic aldehydes, o-aminophenol, copper acetate monohydrate, oxidative cyclization.
Abstract: An efficient synthesis of 2-substituted benzoxazoles via copper acetate monohydrate oxidative coupling of aldehydes with o-aminophenol is described. This synthetic strategy has some advantages as simple procedure, inexpensive and easily available catalyst, and facile isolation of the products in moderate to good yields.
Export Options
About this article
Cite this article as:
Chen Guo-Feng, Shen Hai-Dong, Zhang Li-Yan, Li Hong-Yang, Lan Rui-Jia, Chen Bao-Hua, Li Ji-Tai and Hu Qing-Hui, One-pot Synthesis of 2-Substituted Benzoxazoles Promoted by Copper Acetate Monohydrate, Letters in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/15701786113106660070
DOI https://dx.doi.org/10.2174/15701786113106660070 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease
Current Alzheimer Research Insights into Oxidative Stress: The Isoprostanes
Current Medicinal Chemistry Disrupting β-Amyloid Aggregation for Alzheimer Disease Treatment
Current Topics in Medicinal Chemistry Macrophages in Inflammation
Current Drug Targets - Inflammation & Allergy Ligand and Structure-Based Pharmacophore Modeling for the Discovery of Potential Human HNMT Inhibitors
Letters in Drug Design & Discovery Enriched Environment Prevents Cognitive Impairment and Tau hyperphosphorylation after Chronic Cerebral Hypoperfusion
Current Neurovascular Research Management of Painful Symptoms with Duloxetine: A Review of the Efficacy in Pre-Clinical and Clinical Studies
Current Drug Therapy Immunomodulatory Actions of Vitamin D Metabolites and their Potential Relevance to Human Lung Disease
Current Respiratory Medicine Reviews The Role of Glycoprotein IIb/IIIa Inhibitors- A Promise Not Kept?
Current Cardiology Reviews Immobilization-Induced Behavioral Deficits are Attenuated But Coping with Repeated Stress Impaired in Apomorphine Injected Rats
Current Psychopharmacology Cloning, Expression and Characterization of Mouse (Mus musculus) Nicotinamide 5-Mononucleotide Adenylyltransferase-2
Medicinal Chemistry Molecular Biology of the Enzymes that Degrade Endocannabinoids
Current Drug Targets - CNS & Neurological Disorders Molecular Pharmacology of Non-L-type Calcium Channels
Current Pharmaceutical Design Clopidogrel, Aspirin and Proton Pump Inhibition after Percutaneous Valve Implants: An Update
Current Pharmaceutical Design Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer’s Disease in the Transgenic CRND8 Mice
Current Alzheimer Research Human Tooth Germ Stem Cells Preserve Neuro-Protective Effects after Long-Term Cryo-Preservation
Current Neurovascular Research Cannabinoids and Neuroprotection in Motor-Related Disorders
CNS & Neurological Disorders - Drug Targets Rediscovery of Caffeine: An Excellent Drug for Improving Patient Outcomes while Fighting WARS
Current Medicinal Chemistry Withdrawal Notice: Ionic Liquid Mediated Synthesis of Schiff bases Bearing Thiazole and Indole Moieties
Current Organic Synthesis RAGE and RAGE Ligands in Cancer
Current Molecular Medicine