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Current Enzyme Inhibition


ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Role of Caspases in Activation-Induced Cell Death of Neuroglia

Author(s): Kyoungho Suk

Volume 1, Issue 1, 2005

Page: [43 - 50] Pages: 8

DOI: 10.2174/1573408052952757


Activation-induced cell death (AICD) is an active process. T and B lymphocytes undergo AICD as an auto-regulatory mechanism for the body to remove unwanted activated cells after making appropriate use of them. Recent studies have shown that brain microglia and astrocytes also undergo apoptosis upon inflammatory activation. Caspase-11 has been demonstrated to play a central role in the apoptosis of both microglia and astrocytes following inflammatory activation; inflammatory stimuli induce neuroglial apoptosis through caspases-11, -1, and -3. Thus, inflammatory signals that activate neuroglia may also initiate internal death program, in which caspases play a crucial role. Caspases may be a target for the modulation of neuroglial AICD that has implications in neurodegenerative diseases.

Keywords: apoptosis, caspase, microglia, astrocyte, nitric oxide, inflammation, signal transduction, neurodegenerative diseases

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