Generic placeholder image

Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthesis of Iminosugars from Tetroses

Author(s): Cristina E. Sousa, Raquel R. Mendes, Flora T. Costa, Vera C.M. Duarte, António G. Fortes and Maria J. Alves

Volume 11 , Issue 2 , 2014

Page: [182 - 203] Pages: 22

DOI: 10.2174/15701794113106660074

Price: $65

Abstract

Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to build up iminosugar molecules. Methodologies described herein utilize inexpensive commercial materials. The synthesis of the four tetroses is included referring old and modern methodologies.

Keywords: Erythose, indolizidines, piperidines, pyrrolidines, pyrrolizidines, threose.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy