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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Efficient Copper-catalyzed Cyanation of Aryl Bromides Using 1,3-phenylene- bis-(1H)-tetrazole as an Efficient Ligand

Author(s): Siavash Bahari and Akbar Rezaei

Volume 11, Issue 7, 2014

Page: [519 - 523] Pages: 5

DOI: 10.2174/15701786113109990055

Price: $65


A new method for the synthesis of aryl nitriles has been developed by the cyanation of aryl bromides with K4Fe(CN)6 as a cyanide source in the presence of Cu(OAc)2.H2O as an inexpensive catalyst and a 1,3-phenylene-bis- (1H)-tetrazole ligand. This method has the advantages of high yield, simple methodology and easy work-up.

Keywords: Aryl nitrile, 1, 3-Phenylene-bis-(1H)-tetrazole, Aryl bromide, Cyanation, K4Fe(CN)6, Copper acetate.

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