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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Cyclophilins in Atherosclerosis: A New Therapeutic Target?

Author(s): Michael Bukrinsky, Alexander Orekhov, Michael Ditiatkovski and Dmitri Sviridov

Volume 19, Issue 33, 2013

Page: [5904 - 5908] Pages: 5

DOI: 10.2174/1381612811319330009

Price: $65

Abstract

Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.

Keywords: Extracellular cyclophilins, chemotaxis, inflammation, CD147, leukocytes, monocytes.


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