Abstract
Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
Keywords: Extracellular cyclophilins, chemotaxis, inflammation, CD147, leukocytes, monocytes.
Current Pharmaceutical Design
Title:Cyclophilins in Atherosclerosis: A New Therapeutic Target?
Volume: 19 Issue: 33
Author(s): Michael Bukrinsky, Alexander Orekhov, Michael Ditiatkovski and Dmitri Sviridov
Affiliation:
Keywords: Extracellular cyclophilins, chemotaxis, inflammation, CD147, leukocytes, monocytes.
Abstract: Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
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Cite this article as:
Bukrinsky Michael, Orekhov Alexander, Ditiatkovski Michael and Sviridov Dmitri, Cyclophilins in Atherosclerosis: A New Therapeutic Target?, Current Pharmaceutical Design 2013; 19 (33) . https://dx.doi.org/10.2174/1381612811319330009
DOI https://dx.doi.org/10.2174/1381612811319330009 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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