Antitubercular Drug Development: Current Status and Research Strategies

Kuldipsinh   P.   Barot; Stoyanka      Nikolova; Illiyan      Ivanov; Manjunath   D.   Ghate

Abstract

Recent developments and novel research strategies are adopted widely to discover and develop the new drugs to treat tuberculosis. New antitubercular drugs are urgently needed because tuberculosis remains a global health problem as around nine million new cases are estimated each year with almost two million fatalities. It states the impact and outcomes that have made a significant effect in antitubercular drug development. We are presenting current status of tuberculosis, antitubercular drug development, novel molecular targets, novel agents in clinical and pre-clinical development and some efforts that are being made in the development of novel molecules based on different pharmacophores as lead compounds and recent strategies.

Keywords: Tuberculosis, molecular targets, novel agents in evaluation phase, novel antitubercular agents, novel heterocyclic molecules.

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