Membrane and Soluble Forms of Endoglin in Preeclampsia

B.      Oujo; F.      Perez-Barriocanal; C.      Bernabeu; J.   M.   Lopez-Novoa

Abstract

Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not been elucidated, it has been reported that high levels of endoglin, a TGF-β auxiliary co-receptor, and a soluble form of this protein, occur respectively in the placenta and plasma of women who develop the disease. In this review, the alterations in vasculogenesis and angiogenesis that occur during preeclampsia, the cellular and molecular mechanisms that lead to increased membrane bound endoglin expression and soluble endoglin release, including hypoxia and oxidative stress, and the possible pathogenic role of soluble endoglin in this disease have been analyzed.

Keywords: Endoglin, endothelial dysfunction, hypertension, hypoxia, oxidative stress, placenta, preeclampsia, soluble endoglin.