Indium(III) Catalyzed Direct sp³-sp C-C Bond Formation from Alcohols and Terminal Alkynes

Title:Indium(III) Catalyzed Direct sp³-sp C-C Bond Formation from Alcohols and Terminal Alkynes

Volume: 10 Issue: 8

Author(s): Guangming Nan and Jun Zhou

Affiliation:

Keywords: sp³-sp C-C bond, alkynes, alcohols, indium(III) salts, catalytic synthesis, coupling reaction.

Abstract: A simple and efficient indium(III)-catalyzed sp³-sp C-C bond formation reaction via direct coupling of alcohols with terminal alkynes has been developed under mild conditions without any ligand, base or additive, in which both of aromatic and aliphatic alkynes and various alcohols such as benzylic, allylic and propargylic alcohols can be tolerated. This simple reaction system provides an attractive approach to a large number of internal alkynes in moderate to good yields, and only generates H₂O as the side product.

Cite this article as:

Nan Guangming and Zhou Jun, Indium(III) Catalyzed Direct sp³-sp C-C Bond Formation from Alcohols and Terminal Alkynes, Letters in Organic Chemistry 2013; 10 (8) . https://dx.doi.org/10.2174/1570178611310080004