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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines

Author(s): Ban-Feng Ruan, Si-Qi Wang, Xiao-Lin Ge and Ri-Sheng Yao

Volume 11, Issue 1, 2014

Page: [2 - 9] Pages: 8

DOI: 10.2174/15701808113109990057

Price: $65

Abstract

A new series of resveratrol acrylamides amine derivatives was designed, synthesized, and evaluated for their anti-proliferative activity against three cancer cell lines including human chronic myelocytic leukemia cell K562, human hepatoma HuH-7 and human lung carcinoma A549. Most of the compounds showed superior activity against three cell lines when compared to parent resveratrol. C13 had the best anti-tumor activity against the HuH-7 cell line and its IC50 was 4.5 μmol/L; C16 had the best anti-tumor activity against the K562 cell line and its IC50 was 2.9 μmol/L; C18 had the best anti-tumor activity against the A549 cell line and its IC50 was 3.8 μmol/L. It could be seen that the activity of the aromatic amine derivatives was better than the fatty amine derivatives by analyzing the experimental data.

Keywords: Resveratrol, Acrylamides amine, Anti-proliferative effect, SynthesisResveratrol, Acrylamides amine, Anti-proliferative effect, Synthesis


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