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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

A Genopedia of Lupus Genes - Lessons from Gene Knockouts

Author(s): Yuyuan Guo, Jacob Orme and Chandra Mohan

Volume 9, Issue 2, 2013

Page: [90 - 99] Pages: 10

DOI: 10.2174/1573397111309020003

Price: $65


Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at

Keywords: Systemic Lupus Erythematosus, genetic susceptibility, mouse models.

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