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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

The Development of Pot, Atom and Step Economic (PASE) Synthesis of Functionalised Tetrahydropyrans, Dihydropyrans and Piperidines

Author(s): Paul A. Clarke and Kristaps Ermanis

Volume 17, Issue 18, 2013

Page: [2025 - 2037] Pages: 13

DOI: 10.2174/13852728113179990095

Price: $65


An account of our development of the Pot, Atom and Step Economic (PASE) synthesis of tetrahydropyrans, dihydropyrans and piperidines, based on the Maitland-Japp reaction is given. The value of these reactions as a strategy in natural product synthesis is highlighted and recent further developments of the PASE syntheses in the literature is reported.

Keywords: Dihydropyrans, Multi-component, PASE, Piperidines, Tetrahydropyrans.

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