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Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus

Author(s): Zheng-Kun Zhang, Ming-An Ouyang, Jia-Sui Zhan and Zu-Jian Wu

Volume 9 , Issue 3 , 2013

Page: [247 - 254] Pages: 8

DOI: 10.2174/15734072113099990013

Price: $65

Abstract

Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.

Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.


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