Abstract
Clostridium difficile has become the most common infectious cause of healthcare-associated diarrhea, with serious morbidity, prolonged hospitalization and even death. Treatment of the disease utilizing today’s therapies does not guarantee a successful outcome. In the past decade, many new ideas and inventions have surfaced exploring different treatment strategies of Clostridium difficile associated diarrhea (CDAD). These treatments include antitoxins, novel antimicrobials, immunoglobulins and large inert synthetic compounds. In this paper, we survey of a number of representative patents issued from 2000 to the present targeting treatment of this difficult and dreaded disease.
Keywords: Bacterial toxin, Clostridium difficile, drug target, patents.
Recent Patents on Anti-Infective Drug Discovery
Title:A Surview of Recent Patents on Anti-Infective Therapy for Clostridium difficile
Volume: 8 Issue: 2
Author(s): Germine S. Soliman, Bechoi Saleib and Stephen J. Scholand
Affiliation:
Keywords: Bacterial toxin, Clostridium difficile, drug target, patents.
Abstract: Clostridium difficile has become the most common infectious cause of healthcare-associated diarrhea, with serious morbidity, prolonged hospitalization and even death. Treatment of the disease utilizing today’s therapies does not guarantee a successful outcome. In the past decade, many new ideas and inventions have surfaced exploring different treatment strategies of Clostridium difficile associated diarrhea (CDAD). These treatments include antitoxins, novel antimicrobials, immunoglobulins and large inert synthetic compounds. In this paper, we survey of a number of representative patents issued from 2000 to the present targeting treatment of this difficult and dreaded disease.
Export Options
About this article
Cite this article as:
Soliman S. Germine, Saleib Bechoi and Scholand J. Stephen, A Surview of Recent Patents on Anti-Infective Therapy for Clostridium difficile, Recent Patents on Anti-Infective Drug Discovery 2013; 8 (2) . https://dx.doi.org/10.2174/1574891X113089990016
DOI https://dx.doi.org/10.2174/1574891X113089990016 |
Print ISSN 1574-891X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4071 |
Related Articles
-
Pathogenesis of Diabetic Retinopathy and Diabetic Macular Edema and Enzyme Inhibition
Current Enzyme Inhibition Wound Repair - Updates in Dressing Patents and Regeneration Biomarkers
Recent Patents on Biomarkers Herpes Simplex Encephalitis: From Virus to Therapy
Infectious Disorders - Drug Targets Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome
Current Pharmaceutical Design Current State of Development of Genome Analysis in Livestock
Current Genomics Design of Bioartificial Pancreas with Functional Micro/Nano-Based Encapsulation of Islets
Current Pharmaceutical Biotechnology TGF-β in Epithelial to Mesenchymal Transition and Metastasis of Liver Carcinoma
Current Pharmaceutical Design Alternative Pharmacological Interventions that Limit Myocardial Infarction
Current Medicinal Chemistry Angiogenesis-regulating microRNAs and Ischemic Stroke
Current Vascular Pharmacology Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis
Current Molecular Medicine Current Issues in the Utility of Blood Oxygen Level Dependent MRI for the Assessment of Modulations in Tumor Oxygenation
Current Medical Imaging Antagonists of Activated Factor X and Thrombin: Innovative Antithrombotic Agents.
Current Vascular Pharmacology Chronic Kidney Disease and Thrombosis
Current Pediatric Reviews Current Management and Treatment of Cerebral Vasospasm Complicating SAH
CNS & Neurological Disorders - Drug Targets A Systems Biology Consideration of the Vasculopathy of Sickle Cell Anemia: The Need for Multi-Modality Chemo-Prophylaxis
Cardiovascular & Hematological Disorders-Drug Targets Cardiovascular Effects of Modulators of Soluble Guanylyl Cyclase Activity
Cardiovascular & Hematological Agents in Medicinal Chemistry Nanotechnology in Ophthalmic Drug Delivery: A Survey of Recent Developments and Patenting Activity
Recent Patents on Nanomedicine New Oral Anticoagulants and Their Reversal
Current Drug Safety Evaluating Intestinal Permeability by Measuring Plasma Endotoxin and Diamine Oxidase in Children with Acute Lymphoblastic Leukemia Treated with High-dose Methotrexate
Anti-Cancer Agents in Medicinal Chemistry Tendinopathy and Neovascularization in Rheumatology
Current Rheumatology Reviews