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Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Analytical Applications of Flow Injection Chemiluminescence for the Determination of Pharmaceuticals–A Review

Author(s): Amir Waseem, Mohammad Yaqoob and Abdul Nabi

Volume 9, Issue 4, 2013

Page: [363 - 395] Pages: 33

DOI: 10.2174/15734129113099990002


In this article we present an update on the applications of chemiluminescence coupled with flow injection analysis for the determination of pharmaceuticals. Several reported applications of flow and sequential injection chemiluminescence (FI-CL/SI-CL) in pharmaceuticals concern greatly on quality control, investigation of dissolution of particular formulations or process control of production of pharmaceuticals and their presence in physiological fluids. A number of advances in the development of FI-CL methods have been reported in recent years on pharmaceutical analysis.

In the present review we have covered six years period from Jan-2007 to Dec-2012 discussing FI-CL/SI-CL in the liquid phase as an analytical tool for the determination of pharmaceuticals in diverse samples. We reviewed the methods as per general CL reaction involved with the help of 321 cited references. Interesting features of the FI-CL methods like the use of molecularly imprinting polymers for selectively and specially designed cells/microfluidic devices or lab-on-a-chip for better detection or sensitivity were also presented.

Keywords: Flow injection analysis, sequential injection, chemiluminescence, pharmaceuticals, biomedical applications, microfluidics.

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