Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

Jingwei      Zhang; Xusheng      Shao; Zhong      Li; Xiaoyong      Xu

Abstract

Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).

Keywords: Divalent, Neonicotinoid, Activity, Insecticide.

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Letters in Drug Design & Discovery

Title:Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

Volume: 11 Issue: 2

Author(s): Jingwei Zhang, Xusheng Shao, Zhong Li and Xiaoyong Xu

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Keywords: Divalent, Neonicotinoid, Activity, Insecticide.

Abstract: Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).

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Zhang Jingwei, Shao Xusheng, Li Zhong and Xu Xiaoyong, Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity, Letters in Drug Design & Discovery 2014; 11 (2) . https://dx.doi.org/10.2174/15701808113109990049