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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

Author(s): Hui Sun, Zhaoye Wang and Juan Sebastian Yakisich

Volume 13, Issue 7, 2013

Page: [1048 - 1056] Pages: 9

DOI: 10.2174/18715206113139990130

Price: $65


The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a key regulator of authophagy. Natural products show anticancer activity and often induce apoptosis or autophagy. The crosstalk between these two types of cell death makes autophagy an interesting target since drugs targeting this process not only can induce cell death by inducing autophagy but can also sensitize cells to apoptosis. Autophagy is also a protective mechanism associated with increased resistance to chemotherapy. In this review, we discuss natural products known to induce autophagy cell death in cancer cells via the PI3K/Akt/mTOR pathway.

Keywords: Natural products, PI3K/Akt, autophagy, cancer stem cell, stemness, cell death, anticancer drugs.

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