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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Author(s): Xin Tong and Jill C. Pelling

Volume 13 , Issue 7 , 2013

Page: [971 - 978] Pages: 8

DOI: 10.2174/18715206113139990119

Price: $65


Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.

Keywords: Akt, mTOR, apigenin, cancer.

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