The synthesis and NMR properties of boron analogues of nucleotides and cyclic nucleotides

Title:The synthesis and NMR properties of boron analogues of nucleotides and cyclic nucleotides

Volume: 10 Issue: 9

Author(s): Joanna Nizioł and Tomasz Ruman

Affiliation:

Keywords: Boron nucleotides, cyclic nucleotides, boron nucleosides.

Abstract: The routes of synthesis of the new boron nucleosides – 3’,5’-cyclic boron esters of 2’-deoxycytidine, 2’- deoxyuridine and thymidine along with 3’,5’-bis(pinacolborate) derivatives of 2’-deoxyuridine, 5-fluoro-2’-deoxyuridine and thymidine are presented. The ¹H-, ¹³C- and ¹¹B NMR data of new boron nucleosides are compared with their precursors NMR properties. Presented compounds are in fact boron analogs of nucleotides where boron is in the position of phosphorus atom. New compounds should be at interesting positions as new building blocks in nucleoside and nucleotide chemistry.

Cite this article as:

Nizioł Joanna and Ruman Tomasz, The synthesis and NMR properties of boron analogues of nucleotides and cyclic nucleotides, Letters in Organic Chemistry 2013; 10 (9) . https://dx.doi.org/10.2174/15701786113109990030