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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease

Author(s): Hong-Fang Ji and Liang Shen

Volume 13, Issue 2, 2014

Page: [369 - 373] Pages: 5

DOI: 10.2174/18715273113129990077

Price: $65

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. In recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against PD. Here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of PD, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase B, which endow curcumin with multiple pharmaceutical activities against PD and encourage further studies to investigate its clinical effects.

Keywords: Parkinson's disease, curcumin, antioxidant, anti-inflammation, anti-aggregation.

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