Abstract
Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. In recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against PD. Here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of PD, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase B, which endow curcumin with multiple pharmaceutical activities against PD and encourage further studies to investigate its clinical effects.
Keywords: Parkinson's disease, curcumin, antioxidant, anti-inflammation, anti-aggregation.
CNS & Neurological Disorders - Drug Targets
Title:The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease
Volume: 13 Issue: 2
Author(s): Hong-Fang Ji and Liang Shen
Affiliation:
- Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P.R. China.,China
Keywords: Parkinson's disease, curcumin, antioxidant, anti-inflammation, anti-aggregation.
Abstract: Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. In recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against PD. Here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of PD, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase B, which endow curcumin with multiple pharmaceutical activities against PD and encourage further studies to investigate its clinical effects.
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Cite this article as:
Ji Hong-Fang and Shen Liang, The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease, CNS & Neurological Disorders - Drug Targets 2014; 13(2) . https://dx.doi.org/10.2174/18715273113129990077
DOI https://dx.doi.org/10.2174/18715273113129990077 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |

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