The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease

Title:The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease

Volume: 13 Issue: 2

Author(s): Hong-Fang Ji and Liang Shen

Affiliation:

• Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P.R. China.,China

Keywords: Parkinson's disease, curcumin, antioxidant, anti-inflammation, anti-aggregation.

Abstract: Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. In recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against PD. Here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of PD, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase B, which endow curcumin with multiple pharmaceutical activities against PD and encourage further studies to investigate its clinical effects.

Cite this article as:

Ji Hong-Fang and Shen Liang, The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease, CNS & Neurological Disorders - Drug Targets 2014; 13(2) . https://dx.doi.org/10.2174/18715273113129990077