Abstract
An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.
Letters in Organic Chemistry
Title:Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones
Volume: 10 Issue: 7
Author(s): Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berree, Bertrand Carboni and Abdelmadjid Debache
Affiliation:
Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.
Abstract: An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
Export Options
About this article
Cite this article as:
Sehout Imene, Boulcina Raouf, Boumoud Boudjemaa, Berree Fabienne, Carboni Bertrand and Debache Abdelmadjid, Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones, Letters in Organic Chemistry 2013; 10 (7) . https://dx.doi.org/10.2174/15701786113109990014
DOI https://dx.doi.org/10.2174/15701786113109990014 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
New Insights in Congenital Diaphragmatic Hernia
Current Respiratory Medicine Reviews Combined Brain/Heart Magnetic Resonance Imaging in Systemic Lupus Erythematosus
Current Cardiology Reviews A Pictorial Review of Intracranial Haemorrhage Revisited
Current Medical Imaging Endothelial Dysfunction and Inflammatory Markers of Vascular Disease
Current Vascular Pharmacology Clinical Application of PET Myocardial Perfusion Imaging
Current Medical Imaging Pharmacotherapy of Dilated Cardiomyopathy
Current Pharmaceutical Design The Application of Angiotensin Converting Enzyme Inhibitors in Heart Surgery
Letters in Drug Design & Discovery Technological Barriers in the Use of Electrochemical Microsensors and Microbiosensors for in vivo Analysis of Neurological Relevant Substances
Current Neuropharmacology Clozapine Safety, 40 Years Later
Current Drug Safety Cardiovascular Risk and Quality of Life in Autosomal Dominant Polycystic Kidney Disease Patients on Therapy With Tolvaptan: A Pilot Study
Current Vascular Pharmacology Massively Parallel Screening of the Receptorome
Combinatorial Chemistry & High Throughput Screening Cell-Penetrating Peptides as a Potential Drug Delivery System for Effective Treatment of Diabetes
Current Pharmaceutical Design Nitric Oxide and Oral Diseases: Can We Talk About It?
Cardiovascular & Hematological Agents in Medicinal Chemistry Hypertension and Angiogenesis
Current Pharmaceutical Design Fatty Acid Intakes and Coronary Heart Disease Mortality in Japan: NIPPON DATA90, 1990-2005
Current Nutrition & Food Science Pituitary Dysfunction as a Cause of Cardiovascular Disease
Current Pharmaceutical Design The Benefits and Side Effects of Bevacizumab for the Treatment of Recurrent Ovarian Cancer
Current Drug Targets Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration
Mini-Reviews in Medicinal Chemistry The Inflammation Paradigm and Coronary Artery Disease: What Celsus, Virchow and Gene Knock Outs Have Taught Us
Cardiovascular & Hematological Disorders-Drug Targets The Roles of MicroRNAs in Heart Diseases: A Novel Important Regulator
Current Medicinal Chemistry