Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Title:Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Volume: 10 Issue: 7

Author(s): Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berree, Bertrand Carboni and Abdelmadjid Debache

Affiliation:

Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.

Abstract: An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.

Cite this article as:

Sehout Imene, Boulcina Raouf, Boumoud Boudjemaa, Berree Fabienne, Carboni Bertrand and Debache Abdelmadjid, Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones, Letters in Organic Chemistry 2013; 10 (7) . https://dx.doi.org/10.2174/15701786113109990014