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Current Drug Targets

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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Investigation of Chemical Compounds, Antioxidant and Antimicrobial Properties of Teucrium arduini L. (Lamiaceae)

Author(s): Dario Kremer, Iztok Joze Kosir, Ivan Kosalec, Marijana Zovko Koncic, Tanja Potocnik, Andreja Cerenak, Nada Bezic, Sinisa Srecec and Valerija Dunkic

Volume 14 , Issue 9 , 2013

Page: [1006 - 1014] Pages: 9

DOI: 10.2174/1389450111314090009

Price: $65

Abstract

In this paper chemical composition of the essential oil (analysed by GC and GC-MS), the content of phenolic compounds (analysed by HPLC), quantity of total phenols and total flavonoids (analysed by UV/Vis spectrophotometer), antioxidant and antimicrobial activities of ethanolic extracts were investigated in endemic Teucrium arduini L. in population of Mt Biokovo (Croatia). The oil was characterized by a high concentration of sesquiterpene hydrocarbons (70.4%) of which β-caryophyllene (35.2%) and germacrene D (18.7%) being the major compounds. Three phenolic compounds (quercetin, ferulic acid and rosmarinic acid) were identified and quantified in ethanolic extract of T. arduini using HPLC. The results also showed that T. arduini is a source of polyphenolic and other antioxidants with radical-scavenging and chelating properties. The ethanol extracts prepared from the leaf of T. arduini showed broad spectrum of antimicrobial activity on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus brasiliensis, which are susceptible on concentration below or equal to 4.00 mg/mL, whilst Microsporum gypseum was resistant at investigated concentrations.

Keywords: Antimicrobial activity, antioxidant capacity, essential oils, phenolic compounds, Teucrium arduini.


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