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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Predicting Drug-Target Interactions of Nuclear Receptors Based on Molecular Descriptors Information

Author(s): Junxiang Wang, Weiming Yu, Zhibin Chen, Hengda Li and Zhenran Jiang

Volume 10, Issue 10, 2013

Page: [989 - 994] Pages: 6

DOI: 10.2174/15701808113109100023

Price: $65


Predicting the interaction between drugs and target proteins is one of the most important tasks for bioinformatics. Selecting suitable features for drug-target interaction prediction is an effective way for achieving this important goal. In this article, the molecular descriptors information of drugs combined with several important biological features of nuclear receptor (NR) proteins were first utilized for feature selection. Then, the incremental learning algorithm with support vector machines was used to obtain the optimal feature subset for drug-target interaction prediction. The results demonstrate that the feature selection method can lead to promising improvement on prediction accuracy of this target family.

Keywords: Drug-target interaction, Molecular descriptors, Feature selection.

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