Abstract
Diverse natural product-like N-benzyl cinnamamides were prepared by condensation of trans-cinnamic acid with substituted benzylamines in the presence of boric acid as catalyst. The further evaluation of this amides as a substrates of the bromo-arylation reaction, in the presence of N-bromosuccinimide (NBS) as the halogen source and under the catalysis of Yb(OTf)3, generate a different types of N-substituted amides: N-aryl 2,3-dibromopropanamides, N-(2-bromobenzyl) cinnamamides and tetrahydro-2-benzazepin-3-one as a new molecules. Here we discuss the formation of these main products on the basis of the electronic nature of the substituents present in the N-benzyl aromatic ring of the prepared cinnamamides.
Keywords: N-Aryl 2, 3-dibromopropanamides, N-Benzyl cinnamamides, Boric acid, N-(2-Bromobenzyl) cinnamamides, Tetrahydro-2- benzazepin-3-ones, Yb(OTf)3-Catalyzed bromination reactions.
Current Organic Chemistry
Title:Yb(OTf)3-Catalyzed Bromination Reactions of Natural Product-like N-Benzyl Cinnamamides: A Facile Route to Diverse N-Substituted Amides of Pharmacological Interest
Volume: 17 Issue: 14
Author(s): Carlos E. Puerto Galvis, Jose G. Hernandez Barajas and Vladimir V. Kouznetsov
Affiliation:
Keywords: N-Aryl 2, 3-dibromopropanamides, N-Benzyl cinnamamides, Boric acid, N-(2-Bromobenzyl) cinnamamides, Tetrahydro-2- benzazepin-3-ones, Yb(OTf)3-Catalyzed bromination reactions.
Abstract: Diverse natural product-like N-benzyl cinnamamides were prepared by condensation of trans-cinnamic acid with substituted benzylamines in the presence of boric acid as catalyst. The further evaluation of this amides as a substrates of the bromo-arylation reaction, in the presence of N-bromosuccinimide (NBS) as the halogen source and under the catalysis of Yb(OTf)3, generate a different types of N-substituted amides: N-aryl 2,3-dibromopropanamides, N-(2-bromobenzyl) cinnamamides and tetrahydro-2-benzazepin-3-one as a new molecules. Here we discuss the formation of these main products on the basis of the electronic nature of the substituents present in the N-benzyl aromatic ring of the prepared cinnamamides.
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Cite this article as:
Galvis Puerto Carlos E., Barajas Hernandez Jose G. and Kouznetsov V. Vladimir, Yb(OTf)3-Catalyzed Bromination Reactions of Natural Product-like N-Benzyl Cinnamamides: A Facile Route to Diverse N-Substituted Amides of Pharmacological Interest, Current Organic Chemistry 2013; 17 (14) . https://dx.doi.org/10.2174/1385272811317140009
DOI https://dx.doi.org/10.2174/1385272811317140009 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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