Abstract
Cancer is the main cause of death in developing countries. Its development requires multiple steps in which the occurrence of certain events determines the state transition from a normal to a tumor cell. These events are related to the loss of mechanisms that control various biological processes, which results from the accumulation of genetic alterations, including mutations, chromosomal rearrangements, and variations in gene copy number, as well as from epigenetic alterations. In general, chemotherapeutic agents used for toxicity treatments have shown limited antitumor activity, with a high recurrence rate. This has prompted major research efforts to identify novel effective and selective anti-tumor compounds. In this article, we review recent patents that protect the antitumor properties of natural compounds and related molecules derived from plants, animals, or microorganisms. We consider their structure, mechanism of action, molecular targets and, in some cases, the clinical trial phase reached. We also report on various natural agents that appear to prevent cancer development.
Keywords: Cancer therapy, marine organisms, microorganisms, natural compounds, patent, vegetable.
Recent Patents on Anti-Cancer Drug Discovery
Title:Antitumor Properties of Natural Compounds and Related Molecules
Volume: 8 Issue: 3
Author(s): Inmaculada Robles-Fernandez, Fernando Rodriguez-Serrano, Pablo J. Alvarez, Raul Ortiz, Ana R. Rama, Jose Prados, Consolacion Melguizo, Enrique Alvarez-Manzaneda and Antonia Aranega
Affiliation:
Keywords: Cancer therapy, marine organisms, microorganisms, natural compounds, patent, vegetable.
Abstract: Cancer is the main cause of death in developing countries. Its development requires multiple steps in which the occurrence of certain events determines the state transition from a normal to a tumor cell. These events are related to the loss of mechanisms that control various biological processes, which results from the accumulation of genetic alterations, including mutations, chromosomal rearrangements, and variations in gene copy number, as well as from epigenetic alterations. In general, chemotherapeutic agents used for toxicity treatments have shown limited antitumor activity, with a high recurrence rate. This has prompted major research efforts to identify novel effective and selective anti-tumor compounds. In this article, we review recent patents that protect the antitumor properties of natural compounds and related molecules derived from plants, animals, or microorganisms. We consider their structure, mechanism of action, molecular targets and, in some cases, the clinical trial phase reached. We also report on various natural agents that appear to prevent cancer development.
Export Options
About this article
Cite this article as:
Robles-Fernandez Inmaculada, Rodriguez-Serrano Fernando, Alvarez J. Pablo, Ortiz Raul, Rama R. Ana, Prados Jose, Melguizo Consolacion, Alvarez-Manzaneda Enrique and Aranega Antonia, Antitumor Properties of Natural Compounds and Related Molecules, Recent Patents on Anti-Cancer Drug Discovery 2013; 8 (3) . https://dx.doi.org/10.2174/1574891X113089990034
DOI https://dx.doi.org/10.2174/1574891X113089990034 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
Call for Papers in Thematic Issues
Novel anti-cancer drugs in photoimmunotherapy management: from bench to translational research
In recent years, traditional cancer treatments, such as surgery, chemotherapy, and radiation treatment, etc., may damage the pathological tissue and normal cells. The ideal tumor treatment should be noninvasive, eliminating the primary tumor, making the body produce systemic tumor-specific immunity, eliminating metastases, and having less /no side effects. Recent Patents ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Voltage-Gated Ion Channels, New Targets in Anti-Cancer Research
Recent Patents on Anti-Cancer Drug Discovery Mitochondria and Familial Predisposition to Breast Cancer
Current Genomics Effects of Epirubicin and Cisplatin Against 4T1 Breast Cancer Cells are Enhanced by Myrtucommulone-A
Anti-Cancer Agents in Medicinal Chemistry Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease
Current Pharmaceutical Design Immune Response and Immunotherapy: Live Attenuated Listeria monocytogenes (Lm)-LLO Immunotherapy for the Treatment of Prostate Cancer
Current Cancer Therapy Reviews Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases
Current Pharmacogenomics The Immunohistochemical Expression of the E-Cadherin, Alpha-Catenin,Beta-Catenin and Gamma Catenin Proteins in Epithelial Ovarian Tumours: Relationship with Clinicopathologic Parameters and Patient Survival
Current Women`s Health Reviews An Illustrative Review of Solid Pancreatic Masses: Differential Diagnostic Features of CT and MRI Findings
Current Medical Imaging Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules
Current Medicinal Chemistry Properties of the Mesenchymal Endometriotic Stem Cell in the Context of the Immune System and Analysis of its Role in Endometriosis
Recent Patents on Regenerative Medicine Phage Display Applications for Molecular Imaging
Current Pharmaceutical Biotechnology Targeting Chk2 Kinase: Molecular Interaction Maps and Therapeutic Rationale
Current Pharmaceutical Design Evolution of the Strategies for Screening and Identifying Human Tumor Antigens
Current Protein & Peptide Science Dietary Polyphenols for Prostate Cancer Therapy
Current Bioactive Compounds Potential Role of Natural Compounds Against Skin Aging
Current Medicinal Chemistry NAD Precursors, Mitochondria Targeting Compounds and ADP-Ribosylation Inhibitors in Treatment of Inflammatory Diseases and Cancer
Current Medicinal Chemistry High Throughput Screening of Normal and Neoplastic Tissue Samples
Combinatorial Chemistry & High Throughput Screening Metallothioneins and Platinum(II) Anti-Tumor Compounds
Current Medicinal Chemistry Effect of Environmental Substances on the Activity of Arylamine N-Acetyltransferases
Current Drug Metabolism Green Tea Catechins as Novel Antitumor and Antiangiogenic Compounds
Current Medicinal Chemistry - Anti-Cancer Agents