Abstract
A new and facile one-pot synthesis of the biologically important spiro[quinazoline/pyrimidine]ones scaffold was synthesized simply by the reaction of isatin, 1,3-dione and urea or thiourea. The scope of the reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) instead of isatin. A series of new spiro cyclic derivatives via multi-component reaction was obtained by using guanidine and employing different 1,3 - dicarbonyl compounds.
Keywords: Acenaphthylene-1, 2-dione, 1, 3-Dicarbonyls, dihydropyrimidinone, isatin, multi-component reaction, ninhydrin, spiroheterocycles.
Letters in Organic Chemistry
Title:One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction
Volume: 10 Issue: 6
Author(s): Gangadhar Meshram, Pramod Wagh, Shruti Deshpande and Vipul Amratlal
Affiliation:
Keywords: Acenaphthylene-1, 2-dione, 1, 3-Dicarbonyls, dihydropyrimidinone, isatin, multi-component reaction, ninhydrin, spiroheterocycles.
Abstract: A new and facile one-pot synthesis of the biologically important spiro[quinazoline/pyrimidine]ones scaffold was synthesized simply by the reaction of isatin, 1,3-dione and urea or thiourea. The scope of the reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) instead of isatin. A series of new spiro cyclic derivatives via multi-component reaction was obtained by using guanidine and employing different 1,3 - dicarbonyl compounds.
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Cite this article as:
Meshram Gangadhar, Wagh Pramod, Deshpande Shruti and Amratlal Vipul, One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction, Letters in Organic Chemistry 2013; 10 (6) . https://dx.doi.org/10.2174/1570178611310060006
DOI https://dx.doi.org/10.2174/1570178611310060006 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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