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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Crosstalk between Gut Inflammation and Gastrointestinal Disorders During Acute Pancreatitis

Author(s): Zhen-Zhen Guo, Pu Wang, Zhi-Hui Yi, Zhi-Yin Huang and Cheng-Wei Tang

Volume 20, Issue 7, 2014

Page: [1051 - 1062] Pages: 12

DOI: 10.2174/13816128113199990414

Price: $65


The intestinal inflammation caused by intestinal ischemia reperfusion during acute pancreatitis (AP) often leads to multiple organ dysfunction and aggravation of acute pancreatitis. This review concerns up-date progress of the pathophysiology and molecular mechanism of the excessive production of gut-derived cytokines. The regulation effects of immuno-neuro-endocrine network for pancreatic necrosis are the basis for pharmacological therapeutic in AP. The translation from basic research to clinical trials for the prevention or treatment of severe acute pancreatitis (SAP) is of great value. Early enteral nutrition is necessary for the restitution, proliferation, and differentiation of the intestinal epithelial cells adjacent to the wounded area. Clearance of the excess intestinal bacteria and supplement of probiotics may be helpful to prevent bacterial translocation and infection of pancreas.

Keywords: Acute pancreatitis, intestinal inflammation, intestinal ischemia reperfusion, intestinal barrier, intestinal bacteria, cytokines, somatostatin, tumor necrosis factor-α, melatonin, intestinal restitution, enteral nutrition.

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