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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Amidine-Based Bioactive Compounds for the Regulation of Arginine Metabolism

Author(s): Cristina Maccallini, Marialuigia Fantacuzzi and Rosa Amoroso

Volume 13 , Issue 9 , 2013

Page: [1305 - 1310] Pages: 6

DOI: 10.2174/1389557511313090005

Price: $65


In the research of new bioactive compounds able to regulate the L-arginine metabolism, several substituted amidines were disclosed as potent and selective inhibitors of mainly three enzyme families: the nitric oxide synthase, the dimethylarginine dimethylaminohydrolase and the peptidylarginine deiminase. The present work is focused on the last five years developments in the research for amidine-based inhibitors of the mentioned enzymes and on their potential usefulness in neurodegenerative, inflammatory and autoimmune disorders.

Keywords: Nitric oxide synthase (NOS), dimethylarginine dimethylaminohydrolase (DDAH), peptidylarginine deiminase (PAD), amidines.

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