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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Catalyst-free Alkylation of Aromatic Amines with Aldehydes

Author(s): Qi He, Zhouyu Wang, Shan Qian, Zhenju Jiang, Jianhui Li, Dehong Jiang and Wensi Ai

Volume 10, Issue 5, 2013

Page: [369 - 373] Pages: 5

DOI: 10.2174/1570178611310050012

Price: $65


In the absence of any additional catalysts, a series of aromatic amines were alkylated with a range of aromatic and aliphatic aldehydes. Moderate to excellent isolated yields (up to 94%) were obtained under mild conditions. Simultaneously, the reaction time dramatically shortened from hours to minutes when the Microwave technique was used.

Keywords: Catalyst-free, reductive amination, aldehydes, Hantzsch ester.

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