One-Pot Pseudo Five-Component Green Synthesis of Novel Bis-Betti Bases by the Mannich-Type Reaction

Title:One-Pot Pseudo Five-Component Green Synthesis of Novel Bis-Betti Bases by the Mannich-Type Reaction

Volume: 10 Issue: 5

Author(s): Abolfazl Olyaei and Morteza Rezaei

Affiliation:

Keywords: Terephthaldehyde, heteroaryl amine, naphthol, bis-Betti base, solvent-free, Mannich.

Abstract: A mild, efficient and straightforward method has been developed for the synthesis of novel bis-Betti bases via a pseudo five-component, one-pot condensation reaction of heteroaryl amines, terephthaldehyde and naphthols under solvent- free conditions. The salient features of this protocol are: simple reaction procedure, shorter reaction time, high to excellent yields, avoidance of aqueous work-up, and column chromatographic separation.

Cite this article as:

Olyaei Abolfazl and Rezaei Morteza, One-Pot Pseudo Five-Component Green Synthesis of Novel Bis-Betti Bases by the Mannich-Type Reaction, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050002