Generic placeholder image

Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones

Author(s): Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen and Liang-Xian Liu

Volume 10, Issue 3, 2013

Page: [492 - 499] Pages: 8

DOI: 10.2174/1570179411310030012

Price: $65


A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.

Keywords: Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.

« Previous

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy