Abstract
A 46 years old HIV reactive patient developed Stevens Johnson syndrome (SJS) probably due to nevirapine and/or co-trimoxazole. Patient was on zidovudine + lamivudine + nevirapine along with Co-trimoxazole since last two months. After 15 days, zidovudine was replaced with stavudine due to development of anemia. All these drugs were stopped after development of reaction. Temporal association was found between stavudine, lamivudine, nevirapine, cotrimoxazole and development of the reaction. Nevirapine and Co-trimoxazole were suspected to cause this reaction most probably due to associated hepatotoxicity and their common potential to cause SJS. In our case, patient died despite stopping of all medications.
Keywords: Anti-retroviral therapy, Co-trimoxazole, Hepatotoxicity, HIV, Nevirapine, Stevens Johnson syndrome, Adverse drug reaction.
Current Drug Safety
Title:Nevirapine and/or Co-Trimoxazole Induced Stevens Johnson syndrome in HIV Infected Patient - A Case Report
Volume: 8 Issue: 1
Author(s): Kaksha Patel, Ashwin Panchasara, Bhargav Purohit and C.B. Tripathi
Affiliation:
Keywords: Anti-retroviral therapy, Co-trimoxazole, Hepatotoxicity, HIV, Nevirapine, Stevens Johnson syndrome, Adverse drug reaction.
Abstract: A 46 years old HIV reactive patient developed Stevens Johnson syndrome (SJS) probably due to nevirapine and/or co-trimoxazole. Patient was on zidovudine + lamivudine + nevirapine along with Co-trimoxazole since last two months. After 15 days, zidovudine was replaced with stavudine due to development of anemia. All these drugs were stopped after development of reaction. Temporal association was found between stavudine, lamivudine, nevirapine, cotrimoxazole and development of the reaction. Nevirapine and Co-trimoxazole were suspected to cause this reaction most probably due to associated hepatotoxicity and their common potential to cause SJS. In our case, patient died despite stopping of all medications.
Export Options
About this article
Cite this article as:
Patel Kaksha, Panchasara Ashwin, Purohit Bhargav and Tripathi C.B., Nevirapine and/or Co-Trimoxazole Induced Stevens Johnson syndrome in HIV Infected Patient - A Case Report, Current Drug Safety 2013; 8 (1) . https://dx.doi.org/10.2174/1574886311308010011
DOI https://dx.doi.org/10.2174/1574886311308010011 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protective Effect of Natural Antioxidants on Heart Against Ischemia-Reperfusion Damage
Current Pharmaceutical Biotechnology Type A and B Monoamine Oxidase in Age-Related Neurodegenerative Disorders: Their Distinct Roles in Neuronal Death and Survival
Current Topics in Medicinal Chemistry The Brainstem Tau Cytoskeletal Pathology of Alzheimer’s Disease: A Brief Historical Overview and Description of its Anatomical Distribution Pattern, Evolutional Features, Pathogenetic and Clinical Relevance
Current Alzheimer Research Molecular Rationales for Signal Transduction Therapy and Chemoprevention of BRCA1-Related Breast and Ovarian Tumours
Current Signal Transduction Therapy Morphine as a Potential Oxidative Stress-Causing Agent
Mini-Reviews in Organic Chemistry Recent Progress in Chemically Modified siRNAs
Mini-Reviews in Medicinal Chemistry Amylin Conjugation with Methoxyl Polyethyleneglycol
Protein & Peptide Letters Editorial (Thematic Issue: Protein-protein interaction: from interface to interaction network)
Current Pharmaceutical Design Peroxynitrite-Mediated Structural Changes in Histone H2A: Biochemical and Biophysical Analysis
Protein & Peptide Letters Functional and Structural Roles of GPI Moieties in Mammalian Plasma Membranes
Current Organic Chemistry Mass Spectrometric Identification of Collagen Alpha-1 (III) Chain and Chondroitin Sulfate Proteoglycan-4 Nitration in Patients with Acute Pulmonary Embolism
Current Proteomics 99mTc-HMPAO-Labelled Leukocytes Scintigraphy in Monitoring Children and Adolescents with IBD
Current Radiopharmaceuticals Acknowledgements to the Reviewers:
Inflammation & Allergy - Drug Targets (Discontinued) Current Status of Antiplatelet Therapy in Acute Coronary Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry The Antioxidant Activity of Coumarins and Flavonoids
Mini-Reviews in Medicinal Chemistry Anti-Irritants Agents for the Treatment of Irritant Contact Dermatitis: Clinical and Patent Perspective
Recent Patents on Inflammation & Allergy Drug Discovery Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest
Current Drug Therapy The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown
Current Medicinal Chemistry One-pot Synthesis of Novel Thiophene Containing Aminonaphthols using Fe<sub>3</sub>O<sub>4</sub> Nanoparticles as a Recyclable Heterogeneous Catalyst
Current Catalysis Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus
Current Rheumatology Reviews