Abstract
Mostly anticancer drugs are given as IV infusions, which result in hypertensive reactions due to formulation excipients. Their oral bioavailability is poor or variable due to high liver metabolism, poor aqueous solubility, high Pgp effluxing and macron size. To promote the oral drug delivery of these potential chemotherapeutics, intestinal lymphatic transport has been recognized as a promising route of drug delivery, especially for nanonized cytotoxic drugs because the spread of cancer is much early in lymphatics than the vascular system. A little research has been endeavored to deliver orally, the chemotherapeutics through lymphatic route owing to the complex mechanism involved in their complete absorption. This review will provide insight into the delivery of lipid based nanocarriers through lymphatic transport system for enhancing the oral bioavailability of anticancer moieties.
Keywords: Lipids, intestinal lumen, absorption, lymphatic, anticancer.
Drug Delivery Letters
Title:Lipid based Nanocarriers for Oral Delivery of Cancer Chemotherapeutics: An Insight in the Intestinal Lymphatic Transport
Volume: 3 Issue: 1
Author(s): Javed Ahmad, Kanchan Kohli, Showkat R. Mir and Saima Amin
Affiliation:
Keywords: Lipids, intestinal lumen, absorption, lymphatic, anticancer.
Abstract: Mostly anticancer drugs are given as IV infusions, which result in hypertensive reactions due to formulation excipients. Their oral bioavailability is poor or variable due to high liver metabolism, poor aqueous solubility, high Pgp effluxing and macron size. To promote the oral drug delivery of these potential chemotherapeutics, intestinal lymphatic transport has been recognized as a promising route of drug delivery, especially for nanonized cytotoxic drugs because the spread of cancer is much early in lymphatics than the vascular system. A little research has been endeavored to deliver orally, the chemotherapeutics through lymphatic route owing to the complex mechanism involved in their complete absorption. This review will provide insight into the delivery of lipid based nanocarriers through lymphatic transport system for enhancing the oral bioavailability of anticancer moieties.
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Cite this article as:
Ahmad Javed, Kohli Kanchan, Mir Showkat R. and Amin Saima, Lipid based Nanocarriers for Oral Delivery of Cancer Chemotherapeutics: An Insight in the Intestinal Lymphatic Transport, Drug Delivery Letters 2013; 3 (1) . https://dx.doi.org/10.2174/2210304x11303010006
DOI https://dx.doi.org/10.2174/2210304x11303010006 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
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